Abstract
Many biological oscillators consist of a positive plus a negative feedback loop even though a negative feedback loop is enough to generate oscillations. In this work, we have analyzed from the point of view of the divergence of the system and, hence, the variation of energy in the system, the advantages that the addition of a new loop may provide. We have compared the values of the divergence for negative, negative-plus-negetaive and negative-plus-positive feedback oscillator models. Finally, we have analysed in detail the cyanobacteria circadian oscillator model that has been reproduced in vitro using three proteins: KaiA, KaiB and KaiC plus ATP.